Rapid Quantification of Mean Myocardial Wall Velocity in Ischemic Cardiomyopathy by Cardiac Magnetic Resonance: An Index of Cardiac Functional Abnormalities during the Cardiac Cycle

Methods: 4D LV endocardial function from cine cMR data in 12 NYHA Class III /IV Heart Failure (HF) patients with antero-apical aneurysms was compared against normal controls. The endocardial surface contours were extracted at each cardiac phase using Medviso Segment. An in-house plugin was used to compute a signed Hausdorff Distance (HD), establishing point-correspondences between endocardial segmentations at consecutive cardiac phases and tracking their surface motion throughout the cardiac cycle. The LV averaged myocardial velocity, was computed based on phase-to-phase displacement at several uniformly spaced endocardial surface points and the displacement histories of each point were recorded. The average and standard deviation in the endocardiumaveraged displacement history characteristic curves for the HF patients and normal controls were compared.